has a protective effect against cadmium-induced testicular oxidative stress and apoptosis in the rat. On the basis of the above results, it can be hypothesized that P. Testicular histopathology showed that Cd produced an extensive germ cell apoptosis, and the pretreatment of MEPh in Cd-treated rats significantly reduced Cd-induced testicular damage. Pretreatment with MEPh was associated with significant reduction in the toxic effects of Cd as shown by reduced testicular levels of malondialdehyde, nitric oxide, and caspase-3 expression and increased glutathione content, and the activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and testosterone were also increased.
![cpt code for manual detorsion of testicle cpt code for manual detorsion of testicle](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/1d233943-1c6a-496b-a5f9-4f3e75428a0d/gr2.jpg)
The injection of cadmium caused a significant decrease in body weight, while a significant increase in testes weight and testes weight index was observed. Histopathological changes of testes were examined, and the immunohistochemical staining for the proapoptotic (caspase-3) protein was performed. Oxidative stress markers, antioxidant enzymes, and testosterone level were measured. Changes in body and testes weights were determined. Group 4 was pretreated with MEPh before cadmium for 5 days. Group 3 was orally treated with 200 mg/kg bwt of methanolic extract of physalis (MEPh). Group 2 was intraperitoneally injected with 6.5 mg/kg body weight (bwt) of cadmium chloride for 5 days. They were divided into four groups (n=7). Twenty-eight Wistar albino rats were used. (family Solanaceae) against cadmium-induced testes toxicity in rats. We investigated here the protective effect of Physalis peruviana L. Othman, Mohamed S Nada, Ahmed Zaki, Hassan S Abdel Moneim, Ahmed EĬadmium (Cd) stimulates the production of reactive oxygen species and causes tissue damage. on cadmium-induced testicular toxicity in rats. Genetic Background but not Metallothionein Phenotype Dictates Sensitivity toĬadmium-Induced Testicular Injury in Mice
![cpt code for manual detorsion of testicle cpt code for manual detorsion of testicle](https://www.aafp.org/afp/2013/1215/hi-res/afp20131215p835-ut1.gif)
GENETIC BACKGROUND BUT NOT METALLOTHIONEIN PHENOTYPE DICTATES SENSITIVITY TO CADMIUM-INDUCED TESTICULAR INJURY IN MICE